Aneurysmal Bone Cyst

Client: Nationwide Children’s

Nucleus worked with the interventional radiology team at Nationwide Children’s Hospital to create a series of patient education videos. This animation introduces the viewer to aneurysmal bone cyst formation at a cellular level by visualizing the imbalance between osteoclast and osteoblast activity.

Treatment for this condition involves multiple injections of doxycycline into the cyst. Nucleus uses radiographic imaging to help convey the precision with which these injections are administered. While one needle adds doxycycline to the bone cyst, another one removes fluid from it, allowing the doxycycline foam to expand inside the cyst. Doxycycline kills the cells that dissolve bone (osteoclasts) while enhancing the activity of cells that make bone (osteoblasts), resulting in new healthy bone over time.