Ziopharm’s Controlled IL-12 platform can help provide therapy for cold tumors that exhibit little or no immune system activity by turning them hot. IL-12 is a powerful cytokine and master regulator of the immune system. Ad-RTS-hIL-12 plus veledimex is a gene therapy with an adenoviral vector providing the vehicle engineered to express IL-12 under the control of the RheoSwitch Therapeutic System®. This IL-12 monotherapy is used in combination with checkpoint inhibitors to treat glioblastoma, with therapeutic potential for breast cancer and melanoma.
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